PDX INSIGHTS
PIONEERING CANCER RESEARCH
Leukemia Collection
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Model IDPatient IDPathology Diagnosis
Race
Age at Diagnosis
Gender
Clinical Event PointWBC
MRD
Down Syndrome
CNS
Patient Molecular FeaturesComplete ISCNFlow BlastPatient Treatment
TCH-AML001AML001Acute myeloid leukemiaWhite1.33MaleDiagnosis4052000No3Not Reported47,XY,+8[20].ish ins(10;11)(p1?3;q23q23)(10pter+,wcp10+,wcp11+,5'MLL+;wcp11+, 5'MLL-,3'MLL+,11qter+)902CDA,AAML1031 ADE10,ADE8,AE,Erwinia,HDAC,Ida,MTX,Multiple intensive regimens,PEG-asp,VCR,dexamethasone
TCH-AML002AML002Acute myeloid leukemiaBlack or African American20.04FemaleRefractoryUnknownNot ReportedNoUnknownNot Reportedt(7;21), -17Cytarabine,Fludarabine,Idarubicin,azacitidine,clo,decitabine,thiotepa,topotecan,venetoclax,venetoclax then DLI,vinorelbine
TCH-AML003AML003T-Acute myeloid leukemiaWhite,Hispanic or Latino7.12MaleDiagnosis630No2FLT3 Alteration46,XY,t(11;19)(q23;p13.1)[20]80FLAG,TVTC,Vyxeos,decitabine,vorinostat
TCH-AML004AML004Acute myeloid leukemiaWhite,Hispanic or Latino1.16MaleDiagnosis114502No1IDH246,XY,der(21)t(1;21)(q25;q22)[9]/46,XY[11]25ADE10,ADE8,Decitabine,Enasidanib,FLAG,Vorino,Vyxeos
TCH-AML005aAML005+Acute myeloid leukemiaWhite,Hispanic or Latino16.7MaleDiagnosis3484804No3RAS pathway47,XY,del(11)(q23q25),+21[20]; t(6;11)97ADE10,Azacitidine,Cytarabine,Decitabine,FLAG,Flud,Stem Cell Transplant,Vorino,azacitidine,venetoclax
TCH-AML005bAML005+Acute myeloid leukemiaWhite,Hispanic or Latino16.7MaleRelapse3484804No3RAS pathway47,XY,del(11)(q23q25),+21[20]; t(6;11)ADE10,Azacitidine,Cytarabine,Decitabine,FLAG,Flud,Stem Cell Transplant,Vorino,azacitidine,venetoclax
TCH-AML005cAML005+Acute myeloid leukemiaWhite,Hispanic or Latino16.7MaleRefractory3484804No3RAS pathway47,XY,del(11)(q23q25),+21[20]; t(6;11)ADE10,Azacitidine,Cytarabine,Decitabine,FLAG,Flud,Stem Cell Transplant,Vorino,azacitidine,venetoclax
TCH-AML006AML006Acute myeloid leukemiaBlack or African American9.7MaleRefractory716001.5No2WT1,RAS Pathway46,XY,t(1;6;11)(q21;q27;q23)[19]/46,XY[1]2CDA,ADE10 + GO,ADE8,Idarubicin,asparaginase,cytarabine,etoposide,mitoxantrone
TCH-AML007AML007Acute myeloid leukemiaWhite11.01MaleEnd of Induction10028050No1PICALM-MLLT10,ETV6,Ras Pathway46,XY,t(3;12)(p21;p13),inv(9)(p11q13)c,t(10;11)(p12;q14)[19]/46,XY,inv(9)(p11q13)c[1].ish der(3)t(3;12)(12pter+),der(10)inv(11)(q23q23)t(10;11)(11qter+,5'KMT2A+,3'KMT2A+,10pter-,D10Z1+)ADE10,Aza,Cytarabine,FLAG,Flud,Stem cell transplant,decitabine,vorinostat
TCH-AML009AML009Acute myeloid leukemiaWhite,Hispanic or Latino17.48FemaleRelapse7500No1TP5345,XX, t(11;19)(q23:p13.3),dic(12;13)(p12.p11.1)ADE10,ADE8,FLAG,Stem cell transplant,Vyxeos,azacitidine,cytarabine,decitabine,etoposide,vorinostat
TCH-AML010AML010Acute myeloid leukemiaWhite,Hispanic or Latino2.54MaleDiagnosis678000No1WT147, XY, +1054ADE10,ADE8,asparaginase,cytarabine,etoposide,mitoxantrone
TCH-AML011AML011Acute myeloid leukemiaWhite19.72FemaleDiagnosis397000.7No2FLT3 ITD or ALM,CEBPa or NPM1,WT146, XX89ADE10 + sorafenib,ADE8 + sorafenib,Stem cell transplant,cytarabine,etoposide + sorafenib
TCH-AML012aAML012+Acute myeloid leukemiaWhite,Hispanic or Latino14.44MaleDiagnosis808005No1NUP98-NSD1,FLT3 ITD or ALM,WT147,XY,+8[17]/46,XY[3].ish t(5;11)(q35.3;p15.4)66
TCH-AML012bAML012+Acute myeloid leukemiaWhite,Hispanic or Latino14.44MaleEnd of Induction808005No1NUP98-NSD1,FLT3 ITD or ALM,WT147,XY,+8[17]/46,XY[3].ish t(5;11)(q35.3;p15.4)
TCH-AML013AML013Acute myeloid leukemiaBlack or African American12.91MaleDiagnosis148900Not ReportedNo1Not Reported50,XY,t(6;11)(q27;q23),+der(6)t(6;11),+8,+19,+21[20].90ADE10,ADE8,Decitabine,FLAG,TVTC,asparaginase,cytarabine,etoposide
* indicates the model is private.
+ indicates the patient has multiple models.