PDX Portal

Model Details

Patient Information for Model: BCM-PAN-11

Model Contact

Model: BCM-PAN-11
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PAN-11

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
APC	chr5	112841059	112841059	T	A	c.5465T>A	gTc/gAc	p.V1822D	0.987	6	1	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Benign	COSV57321643	0.794920000000	rs459552	6	1	ENST00000257430.9	Benign	COSV57321643	rs459552
AR	chrX	67546514	67546526	TGGCGGCGGCGGC	T	c.1409_1420del	GGCGGCGGCGGC/-	p.G470_G473del	0.903	17	2	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65964523			17	2	ENST00000374690.9		COSV65964523
ASXL2	chr2	25743545	25743545	G	C	c.2792C>G	aCt/aGt	p.T931S	0.537	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000435504.9			0.000127792000	rs200647261	2	2	ENST00000435504.9			rs200647261
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.999	20	20	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	20	20	ENST00000373344.10	Benign		rs3088074
BARD1	chr2	214728810	214728810	T	C	c.2200A>G	Aca/Gca	p.T734A	0.491	5	2	Missense Variant	Missense Variant	MODERATE	ENST00000260947.9	Uncertain_significance			rs1553612113	5	2	ENST00000260947.9	Uncertain_significance		rs1553612113
BCR	chr22	23292603	23292603	G	A	c.2845G>A	Gtc/Atc	p.V949I	0.42	7	2	Missense Variant	Missense Variant	MODERATE	ENST00000305877.13	Benign/Likely_benign		0.004601100000	rs2229038	7	2	ENST00000305877.13	Benign/Likely_benign		rs2229038
BIRC6	chr2	32415840	32415840	A	G	c.2549A>G	aAa/aGa	p.K850R	0.347	4	2	Missense Variant	Missense Variant	MODERATE	ENST00000421745.6			0.000025373600	rs772164177	4	2	ENST00000421745.6			rs772164177
BRCA2	chr13	32355250	32355250	T	C	c.7397T>C	gTa/gCa	p.V2466A	0.983	5	2	Missense Variant	Missense Variant	MODERATE	ENST00000380152.7	Benign	COSV66451785	0.994912000000	rs169547	5	2	ENST00000380152.7	Benign	COSV66451785	rs169547
BRCA2	chr13	32332922	32332922	C	A	c.1444C>A	Ctt/Att	p.L482I	0.087	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000380152.7	Uncertain_significance	COSV66450724		rs587776460	5	1	ENST00000380152.7	Uncertain_significance	COSV66450724	rs587776460
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.992	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	1.0	10	10	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	10	10	ENST00000330387.11		COSV57791862	rs3217268
CTNND2	chr5	11397050	11397050	G	A	c.593C>T	aCg/aTg	p.T198M	0.667	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000304623.13	Likely_benign	COSV58896382	0.000038040800	rs141302945	2	2	ENST00000304623.13	Likely_benign	COSV58896382	rs141302945
DCC	chr18	52340854	52340854	T	C	c.67T>C	Ttc/Ctc	p.F23L	1.0	6	5	Missense Variant	Missense Variant	MODERATE	ENST00000442544.7	Benign		0.985567000000	rs9951523	6	5	ENST00000442544.7	Benign		rs9951523
ELN	chr7	74056384	74056384	G	A	c.1264G>A	Ggt/Agt	p.G422S	0.265	4	4	Missense Variant	Missense Variant	MODERATE	ENST00000252034.12	Benign	COSV52708305	0.318730000000	rs2071307	4	4	ENST00000252034.12	Benign	COSV52708305	rs2071307
EXT1	chr8	118110795	118110795	C	G	c.252G>C	caG/caC	p.Q84H	0.482	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000378204.7	Uncertain_significance		0.000008444520	rs376231630	2	2	ENST00000378204.7	Uncertain_significance		rs376231630

CNV

Histology Information for Model: BCM-PAN-11

There are no histology images for this model.

Metastasis Information for Model: BCM-PAN-11

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PAN-11

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Reason Stopped
10	Gemcitabine, Radiation Therapy (RT)	Adjuvant	40.7	40.99	106 days	Progressive Disease	Disease Progression
20	Folfox	Adjuvant	41.0	41.31	113 days	Progressive Disease	Disease Progression