PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-10

Model Contact

Model: BCM-PDAC-10
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-10

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AKAP9	chr7	92001075	92001075	A	T	c.1158A>T	aaA/aaT	p.K386N	0.484	15	2	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Conflicting_interpretations_of_pathogenicity		0.000153447000	rs142673316	15	2	ENST00000356239.8	Conflicting_interpretations_of_pathogenicity		rs142673316
ARID1A	chr1	26779439	26779439	T	TG	c.5548dup	-/G	p.D1850Gfs*4	0.555	12	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000324856.13		COSV61371153		rs758608743	12	2	ENST00000324856.13		COSV61371153	rs758608743
ATM	chr11	108254034	108254034	T	C	c.2119T>C	Tct/Cct	p.S707P	0.485	12	4	Missense Variant	Missense Variant	MODERATE	ENST00000278616.8	Benign/Likely_benign	COSV53743430	0.007819920000	rs4986761	12	4	ENST00000278616.8	Benign/Likely_benign	COSV53743430	rs4986761
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.93	20	20	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	20	20	ENST00000373344.10	Benign		rs3088074
BRCA1	chr17	43091823	43091823	A	C	c.3708T>G	aaT/aaG	p.N1236K	0.601	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000357654.9	Benign		0.000240756000	rs28897687	6	2	ENST00000357654.9	Benign		rs28897687
CDKN2A	chr9	21974697	21974697	T	TA	c.130dup	tac/tTac	p.Y44Lfs*76	0.982	7	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000498124.1		COSV58689683			7	2	ENST00000498124.1		COSV58689683
CIITA	chr16	10907072	10907072	G	C	c.1583G>C	gGg/gCg	p.G528A	0.664	24	2	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4		COSV60860610	0.000070089400	rs762177047	24	2	ENST00000618327.4		COSV60860610	rs762177047
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.984	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
COL3A1	chr2	189006417	189006417	G	A	c.3166G>A	Ggt/Agt	p.G1056S	0.217	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000304636.9	Pathogenic	COSV58587172	0.000004222870	rs1223008559	2	2	ENST00000304636.9	Pathogenic	COSV58587172	rs1223008559
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.414	10	10	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	10	10	ENST00000330387.11		COSV57791862	rs3217268
EP300	chr22	41127532	41127532	C	G	c.952C>G	Cca/Gca	p.P318A	0.564	8	2	Missense Variant	Missense Variant	MODERATE	ENST00000263253.9	Conflicting_interpretations_of_pathogenicity	COSV54330481	0.000033767200	rs762647727	8	2	ENST00000263253.9	Conflicting_interpretations_of_pathogenicity	COSV54330481	rs762647727
ERCC2	chr19	45351661	45351661	T	G	c.2251A>C	Aag/Cag	p.K751Q	0.179	16	15	Missense Variant	Missense Variant	MODERATE	ENST00000391945.10	Benign/Likely_benign	COSV67266431	0.322955000000	rs13181	16	15	ENST00000391945.10	Benign/Likely_benign	COSV67266431	rs13181
FAM135B	chr8	138153029	138153030	TG	CA	c.1445_1446inv	cCA/cTG	p.P482L	0.425	4	4	Missense Variant	Missense Variant	MODERATE	ENST00000395297.6				rs71505459	4	4	ENST00000395297.6			rs71505459
FAT3	chr11	92354987	92354987	G	T	c.2425G>T	Gag/Tag	p.E809*	0.35	5	2	Nonsense Mutation	Nonsense Mutation	HIGH	ENST00000525166.5		COSV53186253			5	2	ENST00000525166.5		COSV53186253
HLA-A	chr6	29945061	29945061	A	G	c.1015A>G	Aga/Gga	p.R339G	0.48	8	2	Missense Variant	Missense Variant; Splice Region Variant	MODERATE	ENST00000376809.10			0.000008510710	rs750976599	8	2	ENST00000376809.10			rs750976599

CNV

Histology Information for Model: BCM-PDAC-10

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-10

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-10

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
5	Folfirinox	Neoadjuvant	58.23	58.33	37 days	Partial Response (PR)	Partial Response (pPR); score 2	Side Effects