PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-11

Model Contact

Model: BCM-PDAC-11
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-11

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50814012	50814012	C	T	c.1168G>A	Ggc/Agc	p.G390S	0.37	4	4	Missense Variant	Missense Variant	MODERATE	ENST00000373997.8	Likely_benign		0.005167690000	rs41274050	4	4	ENST00000373997.8	Likely_benign		rs41274050
ACVR1	chr2	157770418	157770418	C	A	c.740G>T	aGg/aTg	p.R247M	0.142	3	3	Missense Variant	Missense Variant	MODERATE	ENST00000434821.7					3	3	ENST00000434821.7
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.535	15	13	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	15	13	ENST00000356239.8		COSV62337888	rs10644111
AKAP9	chr7	92099813	92099813	A	G	c.10840A>G	Atg/Gtg	p.M3614V	0.378	15	4	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV99072410	0.006949960000	rs34327395	15	4	ENST00000356239.8	Benign/Likely_benign	COSV99072410	rs34327395
AR	chrX	67545316	67545316	T	TGCA	c.237_239dup	ctg/ctGCAg	p.Q80dup	0.48	17	2	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000374690.9		COSV65952534			17	2	ENST00000374690.9		COSV65952534
ATRX	chrX	77600552	77600552	T	C	c.5579A>G	aAt/aGt	p.N1860S	0.096	20	1	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign/Likely_benign	COSV64875438	0.006380570000	rs45439799	20	1	ENST00000373344.10	Benign/Likely_benign	COSV64875438	rs45439799
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.48	20	20	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	20	20	ENST00000373344.10	Benign		rs3088074
AXIN2	chr17	65537614	65537614	A	ATGG	c.1419_1421dup	cat/caCCAt	p.H474dup	0.392	8	4	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000307078.10		COSV100195931			8	4	ENST00000307078.10		COSV100195931
BARD1	chr2	214767531	214767532	CA	TG	c.1518_1519inv	caTGtg/caCAtg	p.V507M	0.809	5	4	Missense Variant	Missense Variant	MODERATE	ENST00000260947.9		COSV105837301		rs386654966	5	4	ENST00000260947.9		COSV105837301	rs386654966
BRCA1	chr17	43093819	43093819	A	G	c.1712T>C	aTa/aCa	p.I571T	0.594	6	4	Missense Variant	Missense Variant	MODERATE	ENST00000357654.9	Conflicting_interpretations_of_pathogenicity		0.000012699200	rs80357159	6	4	ENST00000357654.9	Conflicting_interpretations_of_pathogenicity		rs80357159
CIC	chr19	42293072	42293072	G	A	c.3586G>A	Gcc/Acc	p.A1196T	0.362	5	4	Missense Variant	Missense Variant	MODERATE	ENST00000575354.6			0.000114452000	rs199898619	5	4	ENST00000575354.6			rs199898619
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.99	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.379	10	10	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	10	10	ENST00000330387.11		COSV57791862	rs3217268
CREBBP	chr16	3769232	3769246	GTCTCCGTCTTCATT	G	c.2988_3001del	gaAATGAAGACGGAGAcc/gacc	p.E996Dfs*7	0.078	3	3	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000262367.10					3	3	ENST00000262367.10
CTNNA2	chr2	80555765	80555765	G	A	c.1613G>A	cGg/cAg	p.R538Q	0.123	8	4	Missense Variant	Missense Variant	MODERATE	ENST00000402739.8		COSV58141983	0.000026696300	rs374311367	8	4	ENST00000402739.8		COSV58141983	rs374311367

CNV

Histology Information for Model: BCM-PDAC-11

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-11

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-11

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Reason Stopped
25	Gemcitabine	Adjuvant	60.17	60.6	157 days	No evidence of disease	Treatment completed
30	Folfirinox	Adjuvant	60.99	61.07	29 days		Side Effects
35	Folfox	Adjuvant	61.13	61.23	36 days	Stable Disease (SD)	Treatment completed
40	Capecitabine/radiation	Adjuvant	61.3	61.4	37 days	Stable Disease (SD)	Treatment completed
45	Capecitabine	Adjuvant	61.51	61.73	80 days	Progressive Disease (PD)	Stopped due to disease progression
50	Gemcitabine/Abraxane	Adjuvant	61.8	61.85	18 days	Progressive Disease (PD)	Disease progression and clinical decompensation