PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-13

Model Contact

Model: BCM-PDAC-13
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-13

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AFF3	chr2	99593652	99593652	G	C	c.2084C>G	tCg/tGg	p.S695W	0.622	8	4	Missense Variant	Missense Variant	MODERATE	ENST00000409579.5				rs1436457705	8	4	ENST00000409579.5			rs1436457705
APC	chr5	112839514	112839514	T	A	c.3920T>A	aTa/aAa	p.I1307K	0.286	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Conflicting_interpretations_of_pathogenicity&_association&_risk_factor	COSV57326270	0.002012480000	rs1801155	6	2	ENST00000257430.9	Conflicting_interpretations_of_pathogenicity&_association&_risk_factor	COSV57326270	rs1801155
AR	chrX	67545316	67545316	T	TGCAGCAGCAGCAGCA	c.225_239dup	ctg/ctGCAGCAGCAGCAGCAg	p.Q76_Q80dup	0.682	17	2	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000374690.9		COSV65959057			17	2	ENST00000374690.9		COSV65959057
AR	chrX	67546514	67546514	T	TGGCGGC	c.1415_1420dup	-/GGCGGC	p.G472_G473dup	1.0	17	2	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000374690.9					17	2	ENST00000374690.9
CDKN2A	chr9	21971187	21971187	G	A	c.172C>T	Cga/Tga	p.R58*	0.93	7	3	Nonsense Mutation	Nonsense Mutation	HIGH	ENST00000498124.1	Pathogenic	COSV58682666		rs121913387	7	3	ENST00000498124.1	Pathogenic	COSV58682666	rs121913387
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.987	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
ECT2L	chr6	138814569	138814569	G	A	c.145G>A	Gca/Aca	p.A49T	0.948	6	4	Missense Variant	Missense Variant	MODERATE	ENST00000541398.6	not_provided		0.002009010000	rs146769748	6	4	ENST00000541398.6	not_provided		rs146769748
ECT2L	chr6	138876472	138876472	G	A	c.1579G>A	Gaa/Aaa	p.E527K	0.091	6	2	Missense Variant	Missense Variant; Splice Region Variant	MODERATE	ENST00000541398.6	not_provided	COSV100871781	0.277428000000	rs1529151	6	2	ENST00000541398.6	not_provided	COSV100871781	rs1529151
ECT2L	chr6	138876471	138876471	G	C	c.1579-1G>C			0.893	6	3	Splice Acceptor Variant	Splice Acceptor Variant	HIGH	ENST00000541398.6				rs79069095	6	3	ENST00000541398.6			rs79069095
ECT2L	chr6	138865022	138865022	T	G	c.1318T>G	Tgg/Ggg	p.W440G	0.968	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000541398.6	not_provided	COSV62884305	0.005286380000	rs79294486	6	2	ENST00000541398.6	not_provided	COSV62884305	rs79294486
EP300	chr22	41150154	41150154	C	A	c.2773C>A	Cct/Act	p.P925T	0.967	8	2	Missense Variant	Missense Variant	MODERATE	ENST00000263253.9	Benign/Likely_benign	COSV54339374	0.003854000000	rs148884710	8	2	ENST00000263253.9	Benign/Likely_benign	COSV54339374	rs148884710
EZH2	chr7	148828812	148828812	C	G	c.553G>C	Gac/Cac	p.D185H	0.612	11	9	Missense Variant	Missense Variant	MODERATE	ENST00000320356.7	Benign	COSV57449162	0.078149200000	rs2302427	11	9	ENST00000320356.7	Benign	COSV57449162	rs2302427
FAT1	chr4	186708945	186708945	C	T	c.883G>A	Gtg/Atg	p.V295M	0.914	7	4	Missense Variant	Missense Variant	MODERATE	ENST00000441802.7	Likely_benign	COSV101499285	0.003552810000	rs61733573	7	4	ENST00000441802.7	Likely_benign	COSV101499285	rs61733573
FAT4	chr4	125451587	125451587	G	A	c.10571G>A	gGc/gAc	p.G3524D	0.926	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000674496.1	Benign	COSV58676353	0.271591000000	rs1567047	3	1	ENST00000674496.1	Benign	COSV58676353	rs1567047
FGFR4	chr5	177089630	177089630	G	A	c.28G>A	Gtc/Atc	p.V10I	0.723	9	2	Missense Variant	Missense Variant	MODERATE	ENST00000292408.9	Benign	COSV52803790	0.247684000000	rs1966265	9	2	ENST00000292408.9	Benign	COSV52803790	rs1966265

CNV

Histology Information for Model: BCM-PDAC-13

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-13

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-13

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
5	Gemcitabine/Abraxane	Neoadjuvant	64.9	65.09	69 days	Stable Disease (SD); CA 19-9 dropped from 504-184	No Response (NR)	Treatment Completed
15	Gemcitabine/Abraxane	Adjuvant	65.46	65.48	7 days			Poor performance status