PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-19

Model Contact

Model: BCM-PDAC-19
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-19

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AR	chrX	67546752	67546752	G	A	c.1606G>A	Ggg/Agg	p.G536R	0.083	17	2	Missense Variant	Missense Variant	MODERATE	ENST00000374690.9					17	2	ENST00000374690.9
AR	chrX	67546514	67546523	TGGCGGCGGC	T	c.1412_1420del	GGCGGCGGC/-	p.G471_G473del	0.898	17	3	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65963320			17	3	ENST00000374690.9		COSV65963320
ARHGAP26	chr5	143222445	143222445	A	C	c.2279A>C	tAa/tCa	p.760Sext15	0.062	1	1	Loss of Stop Codon	Loss of Stop Codon	HIGH	ENST00000645722.2				rs1811331649	1	1	ENST00000645722.2			rs1811331649
ARID1A	chr1	26697364	26697364	C	T	c.961C>T	Cag/Tag	p.Q321*	0.981	12	2	Nonsense Mutation	Nonsense Mutation	HIGH	ENST00000324856.13					12	2	ENST00000324856.13
ARID1A	chr1	26779717	26779717	C	T	c.5819C>T	cCa/cTa	p.P1940L	0.475	12	2	Missense Variant	Missense Variant	MODERATE	ENST00000324856.13		COSV61376744	0.000004220440	rs773088565	12	2	ENST00000324856.13		COSV61376744	rs773088565
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.949	20	20	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	20	20	ENST00000373344.10	Benign		rs3088074
AXIN2	chr17	65536947	65536947	C	T	c.1829G>A	cGg/cAg	p.R610Q	0.306	8	2	Missense Variant	Missense Variant	MODERATE	ENST00000307078.10	Uncertain_significance	COSV61058100	0.000050762700	rs376248072	8	2	ENST00000307078.10	Uncertain_significance	COSV61058100	rs376248072
BAZ1A	chr14	34773613	34773613	C	G	c.3111G>C	gaG/gaC	p.E1037D	0.798	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000360310.6					1	1	ENST00000360310.6
BCR	chr22	23181025	23181025	G	T	c.65G>T	cGc/cTc	p.R22L	0.657	7	2	Missense Variant	Missense Variant	MODERATE	ENST00000305877.13		COSV99045372	0.000041740700	rs376532812	7	2	ENST00000305877.13		COSV99045372	rs376532812
BIRC3	chr11	102331127	102331127	C	G	c.1210C>G	Cta/Gta	p.L404V	0.45	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000263464.9					2	2	ENST00000263464.9
CBLC	chr19	44793589	44793589	A	AC	c.1255dup	gac/gaCc	p.Q419Pfs*81	0.326	3	3	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000647358.2		COSV54322503			3	3	ENST00000647358.2		COSV54322503
CDH11	chr16	64988331	64988331	C	T	c.825G>A	atG/atA	p.M275I	0.687	2	1	Missense Variant	Missense Variant	MODERATE	ENST00000268603.9	Benign	COSV51754932	0.196252000000	rs1130821	2	1	ENST00000268603.9	Benign	COSV51754932	rs1130821
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.982	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
CLTCL1	chr22	19253972	19253972	C	T	c.506G>A	gGc/gAc	p.G169D	0.326	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000427926.6		COSV54241275	0.000146219000	rs564477345	2	2	ENST00000427926.6		COSV54241275	rs564477345
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.258	10	10	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	10	10	ENST00000330387.11		COSV57791862	rs3217268

CNV

Histology Information for Model: BCM-PDAC-19

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-19

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-19

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
10	Gemcitabine	Adjuvant	72.2		1Unknown	Not Reported	Not Reported	Not Reported