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PIONEERING CANCER RESEARCH
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Pancreas
BCM-PDAC-19
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-PDAC-19
Contact Model Developer
Model Contact
Model: BCM-PDAC-19
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email:
qizhiyao@bcm.edu
Patient Information
Model
: BCM-PDAC-19
Gender
: Female
Race/Ethnicity
: White
Vital Status
: Deceased
Initial Diagnosis
: Pancreatic ductal adenocarcinoma
Age at Diagnosis
: 71.97
Survival in months
: 17.5
Risk Factors
: Tobacco, Diabetes
BMI at Diagnosis
: 29.3
NCCN Stage
: Resectable
Metastasis Sites
:
Clinical Timeline
Clinical Information at Collection
Collection Age
: 71.99
Collection Procedure
: Surgical resection
Clinical Event Point
: Primary
Resection Margin
: R0
Clinical Stage
:
cM
: M0
Clinical Biomarkers/Mutations at Collection
Carbohydrate Antigen 199
:
Bilirubin
:
Pathology Information at Collection
Pathology Diagnosis
: Pancreatic ductal adenocarcinoma
Pathology Grade
: G2
pT
: T3
pN
: N1
pM
: M0
Tumor Stage
: IIB
Treatment Naive
: Yes
Model Information for Model: BCM-PDAC-19
Model Details - Initial Implantation of Patient Tissue
Host Strain
: NSG
Transplant Specimen Condition
: Fresh
Transplant Material
: Tissue Fragment
Transplant Supplements
:
Transplant Site
: Subcutaneous
Humanization
: None
Mouse Sex
:
Tumor Doubling Time
:
Specimen Site
: Pancreas
Mutations (Cancer Gene Census List)
Show/Hide Columns
Total mutations showing: 59
F
P
1
2
3
4
N
E
Rows Per Page
10
15
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50
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Gene
Filter by Gene
Chr
Filter by Chr
Start
End
Ref
Alt
cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
AR
chrX
67546752
67546752
G
A
c.1606G>A
Ggg/Agg
p.G536R
0.083
17
2
Missense Variant
Missense Variant
MODERATE
ENST00000374690.9
17
2
ENST00000374690.9
AR
chrX
67546514
67546523
TGGCGGCGGC
T
c.1412_1420del
GGCGGCGGC/-
p.G471_G473del
0.898
17
3
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000374690.9
COSV65963320
17
3
ENST00000374690.9
COSV65963320
ARHGAP26
chr5
143222445
143222445
A
C
c.2279A>C
tAa/tCa
p.*760Sext*15
0.062
1
1
Loss of Stop Codon
Loss of Stop Codon
HIGH
ENST00000645722.2
rs1811331649
1
1
ENST00000645722.2
rs1811331649
ARID1A
chr1
26697364
26697364
C
T
c.961C>T
Cag/Tag
p.Q321*
0.981
12
2
Nonsense Mutation
Nonsense Mutation
HIGH
ENST00000324856.13
12
2
ENST00000324856.13
ARID1A
chr1
26779717
26779717
C
T
c.5819C>T
cCa/cTa
p.P1940L
0.475
12
2
Missense Variant
Missense Variant
MODERATE
ENST00000324856.13
COSV61376744
0.000004220440
rs773088565
12
2
ENST00000324856.13
COSV61376744
rs773088565
ATRX
chrX
77682471
77682471
C
G
c.2785G>C
Gag/Cag
p.E929Q
0.949
20
20
Missense Variant
Missense Variant
MODERATE
ENST00000373344.10
Benign
rs3088074
20
20
ENST00000373344.10
Benign
rs3088074
AXIN2
chr17
65536947
65536947
C
T
c.1829G>A
cGg/cAg
p.R610Q
0.306
8
2
Missense Variant
Missense Variant
MODERATE
ENST00000307078.10
Uncertain_significance
COSV61058100
0.000050762700
rs376248072
8
2
ENST00000307078.10
Uncertain_significance
COSV61058100
rs376248072
BAZ1A
chr14
34773613
34773613
C
G
c.3111G>C
gaG/gaC
p.E1037D
0.798
1
1
Missense Variant
Missense Variant
MODERATE
ENST00000360310.6
1
1
ENST00000360310.6
BCR
chr22
23181025
23181025
G
T
c.65G>T
cGc/cTc
p.R22L
0.657
7
2
Missense Variant
Missense Variant
MODERATE
ENST00000305877.13
COSV99045372
0.000041740700
rs376532812
7
2
ENST00000305877.13
COSV99045372
rs376532812
BIRC3
chr11
102331127
102331127
C
G
c.1210C>G
Cta/Gta
p.L404V
0.45
2
2
Missense Variant
Missense Variant
MODERATE
ENST00000263464.9
2
2
ENST00000263464.9
CBLC
chr19
44793589
44793589
A
AC
c.1255dup
gac/gaCc
p.Q419Pfs*81
0.326
3
3
Frameshift Mutation
Frameshift Mutation
HIGH
ENST00000647358.2
COSV54322503
3
3
ENST00000647358.2
COSV54322503
CDH11
chr16
64988331
64988331
C
T
c.825G>A
atG/atA
p.M275I
0.687
2
1
Missense Variant
Missense Variant
MODERATE
ENST00000268603.9
Benign
COSV51754932
0.196252000000
rs1130821
2
1
ENST00000268603.9
Benign
COSV51754932
rs1130821
CIITA
chr16
10909070
10909070
A
G
c.2702A>G
cAg/cGg
p.Q901R
0.982
24
24
Missense Variant
Missense Variant
MODERATE
ENST00000618327.4
Benign
0.983235000000
rs7197779
24
24
ENST00000618327.4
Benign
rs7197779
CLTCL1
chr22
19253972
19253972
C
T
c.506G>A
gGc/gAc
p.G169D
0.326
2
2
Missense Variant
Missense Variant
MODERATE
ENST00000427926.6
COSV54241275
0.000146219000
rs564477345
2
2
ENST00000427926.6
COSV54241275
rs564477345
CREB3L2
chr7
137928167
137928170
CTGG
C
c.299_301del
aCCAgt/agt
p.T100del
0.258
10
10
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000330387.11
COSV57791862
rs3217268
10
10
ENST00000330387.11
COSV57791862
rs3217268
Total mutations showing: 59
F
P
1
2
3
4
N
E
Rows Per Page
10
15
25
50
Download
CNV
Histology Information for Model: BCM-PDAC-19
There are no histology images for this model.
Metastasis Information for Model: BCM-PDAC-19
Patient
PDX
Liver
Local recurrence
Lung
Rectum
lymph node
Patient Treatment Information for Model: BCM-PDAC-19
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Pathologic Response
Reason Stopped
10
Gemcitabine
Adjuvant
72.2
1Unknown
Not Reported
Not Reported
Not Reported
Please wait...
Gene
Chr
Start
End
Ref
Alt
cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.