PDX INSIGHTS
PIONEERING CANCER RESEARCH
Model Details

Patient Information for Model: BCM-PDAC-19


Patient Information
Model: BCM-PDAC-19
Gender: Female
Race/Ethnicity: White
Vital Status: Deceased
Initial Diagnosis: Pancreatic ductal adenocarcinoma
Age at Diagnosis: 71.97
Survival in months: 17.5
Risk Factors: Tobacco, Diabetes
BMI at Diagnosis: 29.3
NCCN Stage: Resectable
Metastasis Sites:
Clinical Timeline


Clinical Information at Collection
Collection Age: 71.99
Collection Procedure: Surgical resection
Clinical Event Point: Primary
Resection Margin: R0
Clinical Stage:
cM: M0
Clinical Biomarkers/Mutations at Collection
Carbohydrate Antigen 199:
Bilirubin:
Pathology Information at Collection
Pathology Diagnosis: Pancreatic ductal adenocarcinoma
Pathology Grade: G2
pT: T3
pN: N1
pM: M0
Tumor Stage: IIB
Treatment Naive: Yes

Model Information for Model: BCM-PDAC-19

Model Details - Initial Implantation of Patient Tissue
Host Strain: NSG
Transplant Specimen Condition: Fresh
Transplant Material: Tissue Fragment
Transplant Supplements:
Transplant Site: Subcutaneous
Humanization: None
Mouse Sex:
Tumor Doubling Time:
Specimen Site: Pancreas
Mutations (Cancer Gene Census List)

GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ARchrX6754675267546752GAc.1606G>AGgg/Aggp.G536R0.083172Missense VariantMissense VariantMODERATEENST00000374690.9



172ENST00000374690.9
ARchrX6754651467546523TGGCGGCGGCTc.1412_1420delGGCGGCGGC/-p.G471_G473del0.898173In-frame DeletionIn-frame DeletionMODERATEENST00000374690.9

COSV65963320

173ENST00000374690.9COSV65963320
ARHGAP26chr5143222445143222445ACc.2279A>CtAa/tCap.*760Sext*150.06211Loss of Stop CodonLoss of Stop CodonHIGHENST00000645722.2


rs1811331649
11ENST00000645722.2rs1811331649
ARID1Achr12669736426697364CTc.961C>TCag/Tagp.Q321*0.981122Nonsense MutationNonsense MutationHIGHENST00000324856.13



122ENST00000324856.13
ARID1Achr12677971726779717CTc.5819C>TcCa/cTap.P1940L0.475122Missense VariantMissense VariantMODERATEENST00000324856.13

COSV61376744
0.000004220440rs773088565
122ENST00000324856.13COSV61376744rs773088565
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.9492020Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
2020ENST00000373344.10Benignrs3088074
AXIN2chr176553694765536947CTc.1829G>AcGg/cAgp.R610Q0.30682Missense VariantMissense VariantMODERATEENST00000307078.10
Uncertain_significance
COSV61058100
0.000050762700rs376248072
82ENST00000307078.10Uncertain_significanceCOSV61058100rs376248072
BAZ1Achr143477361334773613CGc.3111G>CgaG/gaCp.E1037D0.79811Missense VariantMissense VariantMODERATEENST00000360310.6



11ENST00000360310.6
BCRchr222318102523181025GTc.65G>TcGc/cTcp.R22L0.65772Missense VariantMissense VariantMODERATEENST00000305877.13

COSV99045372
0.000041740700rs376532812
72ENST00000305877.13COSV99045372rs376532812
BIRC3chr11102331127102331127CGc.1210C>GCta/Gtap.L404V0.4522Missense VariantMissense VariantMODERATEENST00000263464.9



22ENST00000263464.9
CBLCchr194479358944793589AACc.1255dupgac/gaCcp.Q419Pfs*810.32633Frameshift MutationFrameshift MutationHIGHENST00000647358.2

COSV54322503

33ENST00000647358.2COSV54322503
CDH11chr166498833164988331CTc.825G>AatG/atAp.M275I0.68721Missense VariantMissense VariantMODERATEENST00000268603.9
Benign
COSV51754932
0.196252000000rs1130821
21ENST00000268603.9BenignCOSV51754932rs1130821
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9822424Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
2424ENST00000618327.4Benignrs7197779
CLTCL1chr221925397219253972CTc.506G>AgGc/gAcp.G169D0.32622Missense VariantMissense VariantMODERATEENST00000427926.6

COSV54241275
0.000146219000rs564477345
22ENST00000427926.6COSV54241275rs564477345
CREB3L2chr7137928167137928170CTGGCc.299_301delaCCAgt/agtp.T100del0.2581010In-frame DeletionIn-frame DeletionMODERATEENST00000330387.11

COSV57791862
rs3217268
1010ENST00000330387.11COSV57791862rs3217268
CNV


Histology Information for Model: BCM-PDAC-19
There are no histology images for this model.













Metastasis Information for Model: BCM-PDAC-19
 
Patient
PDX
Liver
Local recurrence
Lung
Rectum
lymph node

Patient Treatment Information for Model: BCM-PDAC-19

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
10Gemcitabine Adjuvant72.21UnknownNot ReportedNot Reported Not Reported