PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-25

Model Contact

Model: BCM-PDAC-25
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-25

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AFF4	chr5	132934659	132934659	T	G	c.406A>C	Acc/Ccc	p.T136P	0.504	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000265343.10	Benign		0.002498540000	rs34527550	1	1	ENST00000265343.10	Benign		rs34527550
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	1.0	15	13	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	15	13	ENST00000356239.8		COSV62337888	rs10644111
AKAP9	chr7	92099831	92099831	A	G	c.10858A>G	Atc/Gtc	p.I3620V	0.562	15	1	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign		0.000722067000	rs142729919	15	1	ENST00000356239.8	Benign/Likely_benign		rs142729919
AKAP9	chr7	92083384	92083384	A	G	c.8375A>G	aAt/aGt	p.N2792S	0.512	15	1	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV62339152	0.357813000000	rs6960867	15	1	ENST00000356239.8	Benign/Likely_benign	COSV62339152	rs6960867
AKAP9	chr7	92065387	92065387	A	G	c.6134A>G	aAt/aGt	p.N2045S	0.57	15	1	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign		0.000698774000	rs139963188	15	1	ENST00000356239.8	Benign		rs139963188
ASXL1	chr20	32435107	32435107	G	T	c.2395G>T	Gat/Tat	p.D799Y	0.671	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000375687.10	Benign	COSV60123367	0.001302110000	rs143594454	1	1	ENST00000375687.10	Benign	COSV60123367	rs143594454
ATM	chr11	108244000	108244000	G	C	c.544G>C	Gtt/Ctt	p.V182L	0.418	12	1	Missense Variant	Missense Variant	MODERATE	ENST00000278616.8	Benign/Likely_benign	COSV104592414	0.002512430000	rs3218707	12	1	ENST00000278616.8	Benign/Likely_benign	COSV104592414	rs3218707
BCLAF1	chr6	136278195	136278195	G	C	c.686C>G	cCt/cGt	p.P229R	0.662	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000531224.6			0.000004223760	rs753799977	1	1	ENST00000531224.6			rs753799977
BLM	chr15	90749687	90749687	A	G	c.419A>G	gAa/gGa	p.E140G	0.436	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000355112.8	Benign	COSV104665711	0.002276390000	rs35886055	1	1	ENST00000355112.8	Benign	COSV104665711	rs35886055
BMP5	chr6	55874504	55874504	T	C	c.362A>G	aAt/aGt	p.N121S	0.977	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000370830.4	Benign		0.002300290000	rs35124644	1	1	ENST00000370830.4	Benign		rs35124644
BRCA2	chr13	32355250	32355250	T	C	c.7397T>C	gTa/gCa	p.V2466A	0.999	5	2	Missense Variant	Missense Variant	MODERATE	ENST00000380152.7	Benign	COSV66451785	0.994912000000	rs169547	5	2	ENST00000380152.7	Benign	COSV66451785	rs169547
BRCA2	chr13	32340059	32340059	G	A	c.5704G>A	Gat/Aat	p.D1902N	0.493	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000380152.7	Benign	COSV104430701	0.001345760000	rs4987048	5	1	ENST00000380152.7	Benign	COSV104430701	rs4987048
BRD4	chr19	15243038	15243038	G	T	c.3031C>A	Ccc/Acc	p.P1011T	0.544	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000263377.6					1	1	ENST00000263377.6
CBLC	chr19	44793589	44793589	A	AC	c.1255dup	gac/gaCc	p.Q419Pfs*81	0.433	3	3	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000647358.2		COSV54322503			3	3	ENST00000647358.2		COSV54322503
CDH11	chr16	64972023	64972023	C	T	c.1432G>A	Gtc/Atc	p.V478I	0.425	2	1	Missense Variant	Missense Variant	MODERATE	ENST00000268603.9	Likely_benign		0.000726566000	rs80138971	2	1	ENST00000268603.9	Likely_benign		rs80138971

CNV

Histology Information for Model: BCM-PDAC-25

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-25

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-25

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
10	folfirinox	Neoadjuvant	66.18	66.43	91 days	Stable Disease (SD)	Partial Response (pPR); score 2	Completed regimen