PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-28

Model Contact

Model: BCM-PDAC-28
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-28

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
ABL2	chr1	179108431	179108431	C	T	c.2836G>A	Gtg/Atg	p.V946M	0.918	5	5	Missense Variant	Missense Variant	MODERATE	ENST00000502732.6		COSV61020221	0.000506462000	rs28913889	5	5	ENST00000502732.6		COSV61020221	rs28913889
AFF3	chr2	99593652	99593652	G	C	c.2084C>G	tCg/tGg	p.S695W	0.095	8	4	Missense Variant	Missense Variant	MODERATE	ENST00000409579.5				rs1436457705	8	4	ENST00000409579.5			rs1436457705
APC	chr5	112838202	112838202	C	T	c.2608C>T	Cca/Tca	p.P870S	0.409	6	3	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Benign/Likely_benign	COSV57389158	0.002076830000	rs33974176	6	3	ENST00000257430.9	Benign/Likely_benign	COSV57389158	rs33974176
AR	chrX	67546514	67546529	TGGCGGCGGCGGCGGC	T	c.1406_1420del	GGCGGCGGCGGCGGC/-	p.G469_G473del	0.96	17	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9					17	4	ENST00000374690.9
ARID1A	chr1	26775697	26775697	A	G	c.5114A>G	aAc/aGc	p.N1705S	0.894	12	2	Missense Variant	Missense Variant	MODERATE	ENST00000324856.13	Benign	COSV104411707	0.006846420000	rs61756316	12	2	ENST00000324856.13	Benign	COSV104411707	rs61756316
CDK12	chr17	39526140	39526140	C	T	c.3584C>T	aCg/aTg	p.T1195M	0.423	3	3	Missense Variant	Missense Variant	MODERATE	ENST00000447079.6	not_provided	COSV70999311	0.002212950000	rs61741615	3	3	ENST00000447079.6	not_provided	COSV70999311	rs61741615
CHD4	chr12	6578884	6578884	G	A	c.4943C>T	tCa/tTa	p.S1648L	0.519	3	3	Missense Variant	Missense Variant	MODERATE	ENST00000544040.7	Benign		0.005313810000	rs35512811	3	3	ENST00000544040.7	Benign		rs35512811
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.981	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779
CNTNAP2	chr7	147132408	147132408	C	T	c.1247C>T	gCg/gTg	p.A416V	0.422	3	3	Missense Variant	Missense Variant	MODERATE	ENST00000361727.8	Benign/Likely_benign	COSV62220340	0.001479540000	rs34456867	3	3	ENST00000361727.8	Benign/Likely_benign	COSV62220340	rs34456867
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.921	10	10	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	10	10	ENST00000330387.11		COSV57791862	rs3217268
CRTC3	chr15	90604420	90604420	G	A	c.449G>A	gGg/gAg	p.G150E	0.578	4	3	Missense Variant	Missense Variant	MODERATE	ENST00000268184.11			0.000346079000	rs145024567	4	3	ENST00000268184.11			rs145024567
DAXX	chr6	33320508	33320508	C	T	c.1123G>A	Gtc/Atc	p.V375I	0.573	4	3	Missense Variant	Missense Variant	MODERATE	ENST00000374542.10	Benign	COSV105853115	0.001283900000	rs61737694	4	3	ENST00000374542.10	Benign	COSV105853115	rs61737694
ECT2L	chr6	138814569	138814569	G	A	c.145G>A	Gca/Aca	p.A49T	0.13	6	4	Missense Variant	Missense Variant	MODERATE	ENST00000541398.6	not_provided		0.002009010000	rs146769748	6	4	ENST00000541398.6	not_provided		rs146769748
ECT2L	chr6	138876471	138876471	G	C	c.1579-1G>C			0.107	6	3	Splice Acceptor Variant	Splice Acceptor Variant	HIGH	ENST00000541398.6				rs79069095	6	3	ENST00000541398.6			rs79069095
ECT2L	chr6	138844465	138844465	G	A	c.649G>A	Gtg/Atg	p.V217M	0.906	6	3	Missense Variant	Missense Variant	MODERATE	ENST00000541398.6	not_provided	COSV99056751	0.002871950000	rs75478555	6	3	ENST00000541398.6	not_provided	COSV99056751	rs75478555

CNV

Histology Information for Model: BCM-PDAC-28

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-28

Patient

PDX

Liver

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-28

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
20	Gemcitabine/Abraxane with investigational agent (HALO 301)	Adjuvant	59.34	60.53	434 days	Progressive Disease (PD)	No Response (NR)	Stopped due to disease progression and side effects