PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-2

Model Contact

Model: BCM-PDAC-2
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-2

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.956	15	13	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	15	13	ENST00000356239.8		COSV62337888	rs10644111
AR	chrX	67545316	67545316	T	TGCAGCA	c.234_239dup	ctg/ctGCAGCAg	p.Q79_Q80dup	0.656	17	2	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000374690.9		COSV65953707			17	2	ENST00000374690.9		COSV65953707
AR	chrX	67546514	67546523	TGGCGGCGGC	T	c.1412_1420del	GGCGGCGGC/-	p.G471_G473del	0.896	17	3	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65963320			17	3	ENST00000374690.9		COSV65963320
ARHGAP5	chr14	32093338	32093338	A	AT	c.2676dup	gat/gaTt	p.E893*	0.458	2	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000345122.8		COSV61535007			2	2	ENST00000345122.8		COSV61535007
ARID1A	chr1	26729817	26729818	AG	A	c.1307del	caG/ca	p.G436Afs*183	0.95	12	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000324856.13					12	2	ENST00000324856.13
ATM	chr11	108254034	108254034	T	C	c.2119T>C	Tct/Cct	p.S707P	0.501	12	4	Missense Variant	Missense Variant	MODERATE	ENST00000278616.8	Benign/Likely_benign	COSV53743430	0.007819920000	rs4986761	12	4	ENST00000278616.8	Benign/Likely_benign	COSV53743430	rs4986761
ATR	chr3	142469495	142469495	A	C	c.6394T>G	Tat/Gat	p.Y2132D	0.954	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000350721.9	Benign/Likely_benign	COSV63384218	0.003051310000	rs28910273	2	2	ENST00000350721.9	Benign/Likely_benign	COSV63384218	rs28910273
ATR	chr3	142542712	142542712	T	TA	c.3402dup	-/T	p.N1135*	0.37	2	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000350721.9		COSV63394761			2	2	ENST00000350721.9		COSV63394761
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.929	20	20	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	20	20	ENST00000373344.10	Benign		rs3088074
BRIP1	chr17	61857081	61857081	T	C	c.356A>G	aAt/aGt	p.N119S	0.564	3	2	Missense Variant	Missense Variant	MODERATE	ENST00000259008.7	Uncertain_significance			rs889877039	3	2	ENST00000259008.7	Uncertain_significance		rs889877039
BUB1B	chr15	40220700	40220700	A	C	c.3094A>C	Aac/Cac	p.N1032H	0.989	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000287598.11	Conflicting_interpretations_of_pathogenicity	COSV55010127	0.000709004000	rs34700927	2	2	ENST00000287598.11	Conflicting_interpretations_of_pathogenicity	COSV55010127	rs34700927
CACNA1D	chr3	53769994	53769994	C	T	c.3892C>T	Cct/Tct	p.P1298S	0.408	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000350061.11	Benign	COSV55448703	0.005195230000	rs72556360	2	2	ENST00000350061.11	Benign	COSV55448703	rs72556360
CCDC6	chr10	59793004	59793004	C	CGGAGGT	c.1332_1337dup	ccg/ccACCTCCg	p.P447_P448dup	0.433	2	2	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000263102.7		COSV54054274		rs575393361	2	2	ENST00000263102.7		COSV54054274	rs575393361
CDH1	chr16	68813337	68813337	G	A	c.1162G>A	Gag/Aag	p.E388K	0.457	2	2	Missense Variant	Missense Variant	MODERATE	ENST00000261769.10	Benign	COSV55730651	0.000025322900	rs372838203	2	2	ENST00000261769.10	Benign	COSV55730651	rs372838203
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.989	24	24	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	24	24	ENST00000618327.4	Benign		rs7197779