PDX Portal

Model Details

Patient Information for Model: HCI-001

Model Contact

Model: HCI-001
Model Contact: Alana Welm
Institution: HCI Breast PDX Program
Email: Alana.Welm@hci.utah.edu

Patient Information

Clinical Timeline

Color Keys:

Positive

Negative

N/A

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: HCI-001

Model Details - Initial Implantation of Patient Tissue

Biomarkers & Mutations

Model Details - Acceptable Conditions for Passaging

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50859933	50859933	G	A	c.8C>T	tCa/tTa	p.S3L	0.465	4	1	Missense Variant	Missense Variant	MODERATE	ENST00000373997.8					4	1	ENST00000373997.8
ABL1	chr9	130884719	130884719	C	T	c.2429C>T	cCg/cTg	p.P810L	0.476	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000318560.6	Benign	COSV59335135	0.005338740000	rs2229071	9	1	ENST00000318560.6	Benign	COSV59335135	rs2229071
AFF3	chr2	99593872	99593873	CG	C	c.1863del	gcC/gc	p.D623Tfs*48	0.353	12	5	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000409579.5		COSV57841232		rs201754690	12	5	ENST00000409579.5		COSV57841232	rs201754690
AR	chrX	67546273	67546273	C	T	c.1127C>T	cCc/cTc	p.P376L	0.314	48	1	Missense Variant	Missense Variant	MODERATE	ENST00000374690.9			0.000006391040	rs571209658	48	1	ENST00000374690.9			rs571209658
ATR	chr3	142562511	142562511	C	G	c.891G>C	aaG/aaC	p.K297N	0.389	13	5	Missense Variant	Missense Variant	MODERATE	ENST00000350721.9	Benign/Likely_benign	COSV63384505	0.009925770000	rs2229033	13	5	ENST00000350721.9	Benign/Likely_benign	COSV63384505	rs2229033
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.626	59	56	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	59	56	ENST00000373344.10	Benign		rs3088074
BARD1	chr2	214767531	214767532	CA	TG	c.1518_1519inv	caTGtg/caCAtg	p.V507M	0.972	34	24	Missense Variant	Missense Variant	MODERATE	ENST00000260947.9		COSV105837301		rs386654966	34	24	ENST00000260947.9		COSV105837301	rs386654966
BCL11B	chr14	99257656	99257656	C	T	c.242G>A	tGt/tAt	p.C81Y	0.309	7	1	Missense Variant	Missense Variant	MODERATE	ENST00000357195.8					7	1	ENST00000357195.8
BRAF	chr7	140734722	140734722	G	C	c.2176C>G	Cgc/Ggc	p.R726G	0.278	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000496384.7					5	1	ENST00000496384.7
BRCA2	chr13	32338200	32338202	CTG	C	c.3847_3848del	acTGta/acta	p.V1283Kfs*2	0.955	21	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000380152.7		COSV66451179		rs80359405	21	1	ENST00000380152.7		COSV66451179	rs80359405
CBLB	chr3	105702134	105702134	C	T	c.1919G>A	cGg/cAg	p.R640Q	0.508	7	1	Missense Variant	Missense Variant	MODERATE	ENST00000394030.8			0.000016904600	rs746660756	7	1	ENST00000394030.8			rs746660756
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.975	85	84	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	85	84	ENST00000618327.4	Benign		rs7197779
CLIP1	chr12	122279123	122279123	C	A	c.3670G>T	Gca/Tca	p.A1224S	0.066	4	2	Missense Variant	Missense Variant	MODERATE	ENST00000620786.4	Likely_benign		0.005091810000	rs17881033	4	2	ENST00000620786.4	Likely_benign		rs17881033
COL1A1	chr17	50197978	50197978	G	C	c.613C>G	Cct/Gct	p.P205A	0.048	11	2	Missense Variant	Missense Variant	MODERATE	ENST00000225964.10	Conflicting_interpretations_of_pathogenicity		0.003288860000	rs72667032	11	2	ENST00000225964.10	Conflicting_interpretations_of_pathogenicity		rs72667032
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.973	49	49	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	49	49	ENST00000330387.11		COSV57791862	rs3217268

CNV

Histology Information for Model: HCI-001

There are no histology images for this model.

Metastasis Information for Model: HCI-001

Patient

PDX

Abdomen

Adrenal gland

Bone

Bones

Brain

CTC

Chest

Chest wall

Contralateral Breast

Dura

Fallopian Tubes

Head

Kidney

Liver

Lung

Lymph node

Lymph nodes

Neck

Ovary

Pancreas

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural effusion

Shoulder

Skin

Spine

Spleen

Thoracic Spine

Thymus

Patient Treatment Information for Model: HCI-001

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
10	Paclitaxel	Neoadjuvant	39.67	39.91	88 days	Progressive disease	No Response
20	Radiation Therapy	Adjuvant	40.08	40.16	29 days	Progressive disease	No Response
25	Doxorubicin Liposomal	Adjuvant	40.16	40.25	33 days	Stable Disease	Complete Response	Patient Responded
30	Adriamycin	Adjuvant	40.33	40.41	29 days	Progressive disease	No Response	Patient Died