PDX INSIGHTS
PIONEERING CANCER RESEARCH
Model Details

Patient Information for Model: HCI-002


Patient Information
Model: HCI-002
Gender: Female
Race/Ethnicity: White
Vital Status: Deceased
Initial Diagnosis: Infiltrating ductal carcinoma
Age at Diagnosis: 61
Metastasis Sites: Lymph Node
Germline BRCA1 Status: Not Reported
Germline BRCA2 Status: Not Reported
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Collection Age: 61.00
Collection Procedure: Surgical Excision
Clinical Event Point: Primary
Clinical Biomarkers/Mutations at Collection
Germline BRCA1 Status: Not Reported
Germline BRCA2 Status: Not Reported
Pathology Information at Collection
Pathology Diagnosis: Infiltrating ductal carcinoma
Pathology Grade: G3 (Poorly Differentiated)
pT:
pN:
pM:

Model Information for Model: HCI-002

Model Details - Initial Implantation of Patient Tissue
Host Strain: NOD/SCID and NSG
Transplant Specimen Condition: Unknown
Transplant Material: Tissue Fragement
Matrigel:
Transplant Supplements: None
Transplant Site: Cleared Fat Pad
Humanization: No
Mouse Sex: Female
Tumor Doubling Time: 1 month to 1cm
Specimen Site: Breast
Biomarkers & Mutations
ER Status: Negative
PR Status: Negative
HER2 Status: Negative
BRCA1 Status: Not Reported
BRCA2 Status: Not Reported
Model Details - Acceptable Conditions for Passaging
Permissive Host Strains:
Transplant Specimen Condition:
Transplant Material:
Matrigel:
Transplant Supplements:
Transplant Site:
Humanization:
Mouse Sex:
Mutations (Cancer Gene Census List)

GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ARchrX6754651467546526TGGCGGCGGCGGCTc.1409_1420delGGCGGCGGCGGC/-p.G470_G473del0.594482In-frame DeletionIn-frame DeletionMODERATEENST00000374690.9

COSV65964523

482ENST00000374690.9COSV65964523
ARchrX6754531667545319TGCATc.237_239delctGCAg/ctgp.Q80del0.495489In-frame DeletionIn-frame DeletionMODERATEENST00000374690.9

COSV65954886

489ENST00000374690.9COSV65954886
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.5555956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
BAP1chr35240285752402877CAGTGCCAGCAGCTCCTGCCACc.1891-6_1904del0.95352Splice Acceptor VariantSplice Acceptor Variant; Coding Sequence Variant; Intronic VariantHIGHENST00000460680.6



52ENST00000460680.6
BCORL1chrX130021133130021133CGc.3590C>GgCc/gGcp.A1197G0.102111Missense VariantMissense VariantMODERATEENST00000540052.5



111ENST00000540052.5
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9778584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CNTNAP2chr7147132381147132381AGc.1220A>GaAt/aGtp.N407S0.305102Missense VariantMissense VariantMODERATEENST00000361727.8
Conflicting_interpretations_of_pathogenicity

0.000921550000rs143877693
102ENST00000361727.8Conflicting_interpretations_of_pathogenicityrs143877693
ERCC2chr194535166145351661TGc.2251A>CAag/Cagp.K751Q0.4124846Missense VariantMissense VariantMODERATEENST00000391945.10
Benign/Likely_benign
COSV67266431
0.322955000000rs13181
4846ENST00000391945.10Benign/Likely_benignCOSV67266431rs13181
ESR1chr6151808264151808264TCc.352T>CTcg/Ccgp.S118P0.5102Missense VariantMissense VariantMODERATEENST00000440973.5
Benign

0.004406840000rs200075329
102ENST00000440973.5Benignrs200075329
ETNK1chr122268495122684951GTc.1089G>TgaG/gaTp.E363D0.30832Missense VariantMissense VariantMODERATEENST00000266517.9


0.000102593000rs142528168
32ENST00000266517.9rs142528168
EWSR1chr222929792529297925GAc.1408G>AGgc/Agcp.G470S0.97854Missense VariantMissense VariantMODERATEENST00000414183.6
Uncertain_significance
COSV58428629
0.007975060000rs41311143
54ENST00000414183.6Uncertain_significanceCOSV58428629rs41311143
GATA2chr3128486108128486108CTc.490G>AGcc/Accp.A164T0.517139Missense VariantMissense VariantMODERATEENST00000341105.7
Benign
COSV62003051
0.199868000000rs2335052
139ENST00000341105.7BenignCOSV62003051rs2335052
HLA-Achr62994450329944504TGCAc.899_900invcTG/cCAp.L300P0.272411Missense VariantMissense VariantMODERATEENST00000376809.10


rs35946537
2411ENST00000376809.10rs35946537
IRS4chrX108735112108735113TCATc.1232_1233delinsATcGA/cATp.R411H0.488133Missense VariantMissense VariantMODERATEENST00000372129.3


rs375938401
133ENST00000372129.3rs375938401
KEAP1chr191048666610486669TCTGTc.1858_1860delCAG/-p.Q620del0.51422In-frame DeletionIn-frame DeletionMODERATEENST00000171111.10

COSV104383915
rs559787043
22ENST00000171111.10COSV104383915rs559787043
CNV


Histology Information for Model: HCI-002
There are no histology images for this model.













Metastasis Information for Model: HCI-002
 
Patient
PDX
Abdomen
Adrenal gland
Bone
Bones
Brain
CTC
Chest
Chest wall
Contralateral Breast
Dura
Fallopian Tubes
Head
Kidney
Liver
Lung
Lymph node
Lymph nodes
Neck
Ovary
Pancreas
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural effusion
Shoulder
Skin
Spine
Spleen
Thoracic Spine
Thymus

Patient Treatment Information for Model: HCI-002

Event IdTreatmentTreatment SettingAge at StartAge at EndDuration
10Radiation TherapyAdjuvant61.0861.1629 days
15ZometaAdjuvant61.6761.7529 days