PDX Portal

Model Details

Patient Information for Model: HCI-009

Model Contact

Model: HCI-009
Model Contact: Alana Welm
Institution: HCI Breast PDX Program
Email: Alana.Welm@hci.utah.edu

Patient Information

Clinical Timeline

Color Keys:

Positive

Negative

N/A

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: HCI-009

Model Details - Initial Implantation of Patient Tissue

Biomarkers & Mutations

Model Details - Acceptable Conditions for Passaging

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
ACVR2A	chr2	147896450	147896450	G	C	c.205G>C	Ggt/Cgt	p.G69R	0.224	2	1	Missense Variant	Missense Variant	MODERATE	ENST00000241416.12					2	1	ENST00000241416.12
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.546	50	35	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	50	35	ENST00000356239.8		COSV62337888	rs10644111
ASXL2	chr2	25768820	25768820	T	C	c.553A>G	Agc/Ggc	p.S185G	0.833	8	1	Missense Variant	Missense Variant	MODERATE	ENST00000435504.9	Benign	COSV55468898	0.001826880000	rs147191545	8	1	ENST00000435504.9	Benign	COSV55468898	rs147191545
ATR	chr3	142459302	142459302	C	T	c.7274G>A	cGa/cAa	p.R2425Q	0.099	13	1	Missense Variant	Missense Variant	MODERATE	ENST00000350721.9	Benign	COSV63383988	0.130080000000	rs2229032	13	1	ENST00000350721.9	Benign	COSV63383988	rs2229032
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.905	59	56	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	59	56	ENST00000373344.10	Benign		rs3088074
BAP1	chr3	52402857	52402877	CAGTGCCAGCAGCTCCTGCCA	C	c.1891-6_1904del			0.097	5	2	Splice Acceptor Variant	Splice Acceptor Variant; Coding Sequence Variant; Intronic Variant	HIGH	ENST00000460680.6					5	2	ENST00000460680.6
CDH1	chr16	68823627	68823627	G	C	c.2164+1G>C			0.762	7	1	Splice Donor Variant	Splice Donor Variant	HIGH	ENST00000261769.10		COSV105851736		rs1961238458	7	1	ENST00000261769.10		COSV105851736	rs1961238458
CHD2	chr15	92939634	92939634	A	G	c.608A>G	aAa/aGa	p.K203R	0.33	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000394196.9	Benign/Likely_benign	COSV99046909	0.003267480000	rs117844037	5	1	ENST00000394196.9	Benign/Likely_benign	COSV99046909	rs117844037
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.977	85	84	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	85	84	ENST00000618327.4	Benign		rs7197779
CNTNAP2	chr7	147132381	147132381	A	G	c.1220A>G	aAt/aGt	p.N407S	0.063	10	2	Missense Variant	Missense Variant	MODERATE	ENST00000361727.8	Conflicting_interpretations_of_pathogenicity		0.000921550000	rs143877693	10	2	ENST00000361727.8	Conflicting_interpretations_of_pathogenicity		rs143877693
CSF1R	chr5	150077401	150077401	T	A	c.764A>T	aAc/aTc	p.N255I	0.424	6	1	Missense Variant	Missense Variant	MODERATE	ENST00000286301.7	Benign/Likely_benign	COSV53838127	0.000692264000	rs146406037	6	1	ENST00000286301.7	Benign/Likely_benign	COSV53838127	rs146406037
CSMD3	chr8	112265538	112265538	A	T	c.9561T>A	gaT/gaA	p.D3187E	0.402	24	1	Missense Variant	Missense Variant	MODERATE	ENST00000297405.10				rs1222062601	24	1	ENST00000297405.10			rs1222062601
CTNND1	chr11	57796710	57796710	G	A	c.674G>A	aGt/aAt	p.S225N	0.27	4	1	Missense Variant	Missense Variant	MODERATE	ENST00000399050.10					4	1	ENST00000399050.10
DCC	chr18	52340854	52340854	T	C	c.67T>C	Ttc/Ctc	p.F23L	0.896	15	6	Missense Variant	Missense Variant	MODERATE	ENST00000442544.7	Benign		0.985567000000	rs9951523	15	6	ENST00000442544.7	Benign		rs9951523
ERBB3	chr12	56087836	56087836	T	A	c.655T>A	Ttt/Att	p.F219I	0.445	14	1	Missense Variant	Missense Variant	MODERATE	ENST00000267101.8					14	1	ENST00000267101.8

CNV

Histology Information for Model: HCI-009

There are no histology images for this model.

Metastasis Information for Model: HCI-009

Patient

PDX

Abdomen

Adrenal gland

Bone

Bones

Brain

CTC

Chest

Chest wall

Contralateral Breast

Dura

Fallopian Tubes

Head

Kidney

Liver

Lung

Lymph node

Lymph nodes

Neck

Ovary

Pancreas

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural effusion

Shoulder

Skin

Spine

Spleen

Thoracic Spine

Thymus

Patient Treatment Information for Model: HCI-009

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Reason Stopped
10	Radiation Therapy	Neoadjuvant	42.08	42.16	29 days
15	Cyclophosphamide, Methotrexate, 5-Fluorouracil	Neoadjuvant	42.25	42.41	58 days	Progressive disease
20	Tamoxifen, Anastrozole	Neoadjuvant	44.08	65.08	7665 days	Progressive disease
25	Radiation Hip	Neoadjuvant	64.0	64.08	29 days	Progressive disease
30	Paclitaxel	Neoadjuvant	65.08	65.16	29 days	Progressive disease
35	Zolendronic Acid	Neoadjuvant	65.25	65.33	29 days	Progressive disease
40	Fulvestrant	Neoadjuvant	65.41	65.5	33 days	Progressive disease
45	Alternative Medicine	Neoadjuvant	65.67	65.91	88 days	Progressive disease	Patient Died