PDX Portal

Model Details

Patient Information for Model: HCI-010

Model Contact

Model: HCI-010
Model Contact: Alana Welm
Institution: HCI Breast PDX Program
Email: Alana.Welm@hci.utah.edu

Patient Information

Clinical Timeline

Color Keys:

Positive

Negative

N/A

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: HCI-010

Model Details - Initial Implantation of Patient Tissue

Biomarkers & Mutations

Model Details - Acceptable Conditions for Passaging

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
ABL2	chr1	179108478	179108478	T	C	c.2789A>G	aAa/aGa	p.K930R	0.461	7	3	Missense Variant	Missense Variant	MODERATE	ENST00000502732.6	Benign	COSV99048946	0.008745050000	rs17277288	7	3	ENST00000502732.6	Benign	COSV99048946	rs17277288
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.483	50	35	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	50	35	ENST00000356239.8		COSV62337888	rs10644111
AR	chrX	67545316	67545316	T	TGCA	c.237_239dup	ctg/ctGCAg	p.Q80dup	0.372	48	3	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000374690.9		COSV65952534			48	3	ENST00000374690.9		COSV65952534
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.E929Q	0.963	59	56	Missense Variant	Missense Variant	MODERATE	ENST00000373344.10	Benign			rs3088074	59	56	ENST00000373344.10	Benign		rs3088074
BARD1	chr2	214767531	214767532	CA	TG	c.1518_1519inv	caTGtg/caCAtg	p.V507M	0.987	34	24	Missense Variant	Missense Variant	MODERATE	ENST00000260947.9		COSV105837301		rs386654966	34	24	ENST00000260947.9		COSV105837301	rs386654966
BRCA1	chr17	43104218	43104218	A	AG	c.344dup	cct/ccCt	p.E116*	0.939	19	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000357654.9					19	1	ENST00000357654.9
BRCA1	chr17	43104262	43104262	C	A	c.302-1G>T			0.977	19	1	Splice Acceptor Variant	Splice Acceptor Variant	HIGH	ENST00000357654.9				rs80358116	19	1	ENST00000357654.9			rs80358116
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.965	85	84	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	85	84	ENST00000618327.4	Benign		rs7197779
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.5	49	49	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	49	49	ENST00000330387.11		COSV57791862	rs3217268
DCC	chr18	53066161	53066161	A	G	c.1256A>G	aAg/aGg	p.K419R	0.963	15	1	Missense Variant	Missense Variant	MODERATE	ENST00000442544.7	Conflicting_interpretations_of_pathogenicity	COSV105175169	0.002878470000	rs144623089	15	1	ENST00000442544.7	Conflicting_interpretations_of_pathogenicity	COSV105175169	rs144623089
DNM2	chr19	10829156	10829156	C	T	c.2179C>T	Cat/Tat	p.H727Y	0.97	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000389253.9	Conflicting_interpretations_of_pathogenicity		0.000274438000	rs142963320	6	2	ENST00000389253.9	Conflicting_interpretations_of_pathogenicity		rs142963320
ERCC2	chr19	45351661	45351661	T	G	c.2251A>C	Aag/Cag	p.K751Q	0.419	48	46	Missense Variant	Missense Variant	MODERATE	ENST00000391945.10	Benign/Likely_benign	COSV67266431	0.322955000000	rs13181	48	46	ENST00000391945.10	Benign/Likely_benign	COSV67266431	rs13181
FAM135B	chr8	138153029	138153030	TG	CA	c.1445_1446inv	cCA/cTG	p.P482L	0.978	35	29	Missense Variant	Missense Variant	MODERATE	ENST00000395297.6				rs71505459	35	29	ENST00000395297.6			rs71505459
FBLN2	chr3	13636509	13636509	G	C	c.3279G>C	caG/caC	p.Q1093H	0.238	6	1	Missense Variant	Missense Variant	MODERATE	ENST00000404922.8					6	1	ENST00000404922.8
FLT4	chr5	180618911	180618911	G	A	c.2860C>T	Ccc/Tcc	p.P954S	0.976	12	1	Missense Variant	Missense Variant	MODERATE	ENST00000261937.11	Conflicting_interpretations_of_pathogenicity	COSV56128641	0.003490450000	rs34255532	12	1	ENST00000261937.11	Conflicting_interpretations_of_pathogenicity	COSV56128641	rs34255532

CNV

Histology Information for Model: HCI-010

There are no histology images for this model.

Metastasis Information for Model: HCI-010

Patient

PDX

Abdomen

Adrenal gland

Bone

Bones

Brain

CTC

Chest

Chest wall

Contralateral Breast

Dura

Fallopian Tubes

Head

Kidney

Liver

Lung

Lymph node

Lymph nodes

Neck

Ovary

Pancreas

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural effusion

Shoulder

Skin

Spine

Spleen

Thoracic Spine

Thymus

Patient Treatment Information for Model: HCI-010

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Reason Stopped
10	Radiation to the chest wall, supraclavicular nodes and axilla	Neoadjuvant	47.08	47.16	29 days
15	Cyclophosphamide , Doxorubicin , Paclitaxel	Neoadjuvant	47.25	47.33	29 days	Progressive disease
20	Liposomal Doxorubicin	Neoadjuvant	48.41	48.5	33 days	Progressive disease
25	Zolendronic Acid	Neoadjuvant	48.61	48.71	37 days	Progressive disease
30	Capcitabine	Neoadjuvant	48.75	48.91	58 days	Progressive disease
35	Doxetaxel	Neoadjuvant	48.83	48.91	29 days	Progressive disease	Patient Died