PDX INSIGHTS
PIONEERING CANCER RESEARCH
Publications
Lee JJY, Johnston MJ, Farooq H, Chen HM, Younes ST, Suarez R, Zwaig M, Juretic N, Weiss WA, Ragoussis J, Jabado N, Taylor MD, Gallo M. (2024). 3D genome topology distinguishes molecular subgroups of medulloblastoma.   American journal of human genetics, 111, (12), 2720-2734. doi: 10.1016/j.ajhg.2024.10.003. 39481374
Strope BS, Pendleton KE, Bowie WZ, Echeverria GV, Zhu Q. (2024). Xenomake: a pipeline for processing and sorting xenograft reads from spatial transcriptomic experiments.   Bioinformatics (Oxford, England), 40, (11), . doi: 10.1093/bioinformatics/btae608. 39400332
Massey S, Kongchan N, Gao Y, Chaudhury A, Olokpa E, Karch J, Malovannaya A, Cheng C, Zhang X, Neilson JR. (2024). PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells.   The Journal of biological chemistry, 300, (11), 107826. doi: 10.1016/j.jbc.2024.107826. 39343007
Talwar C, Davuluri GVN, Kamal AHM, Coarfa C, Han SJ, Veeraragavan S, Parsawar K, Putluri N, Hoffman K, Jimenez P, Biest S, Kommagani R. (2024). Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies.   Med (New York, N.Y.), , (), . pii: S2666-6340(24)00373-8. doi: 10.1016/j.medj.2024.09.006. 39395412
Berner MJ, Beasley HK, Vue Z, Lane A, Vang L, Baek ML, Marshall AG, Killion M, Zeleke F, Shao B, Parker D, Peterson A, Rhoades JS, Scudese E, Dobrolecki LE, Lewis MT, Hinton A Jr, Echeverria GV. (2024). Three-dimensional analysis of mitochondria in a patient-derived xenograft model of triple negative breast cancer reveals mitochondrial network remodeling following chemotherapy treatments.   bioRxiv : the preprint server for biology, , (), . pii: 2024.09.09.611245. doi: 10.1101/2024.09.09.611245. 39314272
Nipper AJ, Warren EAK, Liao KS, Liu HC, Michikawa C, Porter CE, Wells GA, Villanueva M, Brasil da Costa FH, Veeramachaneni R, Villanueva H, Suzuki M, Sikora AG. (2024). Chick Embryo Chorioallantoic Membrane as a Platform for Assessing the In Vivo Efficacy of Chimeric Antigen Receptor T-cell Therapy in Solid Tumors.   ImmunoHorizons, 8, (8), 598-605. doi: 10.4049/immunohorizons.2400059. 39225630
Meric-Bernstam F, Lloyd MW, Koc S, Evrard YA, McShane LM, Lewis MT, Evans KW, Li D, Rubinstein L, Welm A, Dean DA 2nd, Srivastava A, Grover JW, Ha MJ, Chen H, Huang X, Varadarajan K, Wang J, Roth JA, Welm B, Govinden R, Ding L, Kaochar S, Mitsiades N, Carvajal-Carmona L, Herylyn M, Davies MA, Shapiro GI, Fields R, Trevino JG, Harrell JC, NCI PDXNet Consortium, Doroshow JH, Chuang JH, Moscow JA. (2024). Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations.   Molecular cancer therapeutics, 23, (7), 924-938. doi: 10.1158/1535-7163.MCT-23-0471. 38641411
Murthy D, Dutta D, Attri KS, Samanta T, Yang S, Jung KH, Latario SG, Putluri V, Huang S, Putluri N, Park JH, Kaipparettu BA. (2024). CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.   Cancer letters, 587, (), 216724. doi: 10.1016/j.canlet.2024.216724. 38373689
Espinoza AF, Patel RH, Patel KR, Badachhape AA, Whitlock R, Srivastava RK, Govindu SR, Duong A, Kona A, Kureti P, Armbruster B, Kats D, Srinivasan RR, Dobrolecki LE, Yu X, Najaf Panah MJ, Zorman B, Sarabia SF, Urbicain M, Major A, Bissig KD, Keller C, Lewis MT, Heczey A, Sumazin P, López-Terrada DH, Woodfield SE, Vasudevan SA. (2024). A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma.   Journal of hepatology, 80, (4), 610-621. doi: 10.1016/j.jhep.2024.01.003. 38242326
Lewis MT, Caldas C. (2024). The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer.   Cold Spring Harbor perspectives in medicine, 14, (4), . doi: 10.1101/cshperspect.a041329. 38052483
Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, Huang S, Ellis MJ, Apolo AB, Ballester LY, Gao J, Hansel DE, Lotan Y, Hodges HC, Lerner SP, Creighton CJ, Sreekumar A, Zheng WJ, Msaouel P, Kavuri SM, Putluri N. (2024). The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.   Nature communications, 15, (1), 1373. doi: 10.1038/s41467-024-45132-2. 38355560
Qian J, Ma Y, Tahaney WM, Moyer CL, Lanier A, Hill J, Coleman D, Koupaei N, Hilsenbeck SG, Savage MI, Page BDG, Mazumdar A, Brown PH. (2024). The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.   Breast cancer research : BCR, 26, (1), 23. doi: 10.1186/s13058-024-01778-w. 38317231
Saltzman AB, Chan DW, Holt MV, Wang J, Jaehnig EJ, Anurag M, Singh P, Malovannaya A, Kim BJ, Ellis MJ. (2024). Kinase inhibitor pulldown assay (KiP) for clinical proteomics.   Clinical proteomics, 21, (1), 3. doi: 10.1186/s12014-023-09448-3. 38225548
Liu Q, Zhang J, Guo C, Wang M, Wang C, Yan Y, Sun L, Wang D, Zhang L, Yu H, Hou L, Wu C, Zhu Y, Jiang G, Zhu H, Zhou Y, Fang S, Zhang T, Hu L, Li J, Liu Y, Zhang H, Zhang B, Ding L, Robles AI, Rodriguez H, Gao D, Ji H, Zhou H, Zhang P. (2024). Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies.   Cell, 187, (1), 184-203.e28. doi: 10.1016/j.cell.2023.12.004. 38181741
Lin FT, Liu K, Garan LAW, Folly-Kossi H, Song Y, Lin SJ, Lin WC. (2023). A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors.   Proceedings of the National Academy of Sciences of the United States of America, 120, (44), e2307793120. doi: 10.1073/pnas.2307793120. 37878724
Gou X, Kim BJ, Anurag M, Lei JT, Young MN, Holt MV, Fandino D, Vollert CT, Singh P, Alzubi MA, Malovannaya A, Dobrolecki LE, Lewis MT, Li S, Foulds CE, Ellis MJ. (2023). Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer.   Cancer research, 83, (19), 3237-3251. doi: 10.1158/0008-5472.CAN-22-3484. 37071495
Strope BS, Pendleton KE, Bowie WZ, Echeverria GV, Zhu Q. (2023). Xenomake: a pipeline for processing and sorting xenograft reads from spatial transcriptomic experiments.   bioRxiv : the preprint server for biology, , (), . pii: 2023.09.04.556109. doi: 10.1101/2023.09.04.556109. 37732227
Fu X, Pereira R, Liu CC, De Angelis C, Shea MJ, Nanda S, Qin L, Mitchell T, Cataldo ML, Veeraraghavan J, Sethunath V, Giuliano M, Gutierrez C, Győrffy B, Trivedi MV, Cohen O, Wagle N, Nardone A, Jeselsohn R, Rimawi MF, Osborne CK, Schiff R. (2023). High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer.   Cell reports, 42, (8), 112821. doi: 10.1016/j.celrep.2023.112821. 37467106
Murillo OD, Petrosyan V, LaPlante EL, Dobrolecki LE, Lewis MT, Milosavljevic A. (2023). Deconvolution of cancer cell states by the XDec-SM method.   PLoS computational biology, 19, (8), e1011365. doi: 10.1371/journal.pcbi.1011365. 37578979
Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG. (2023). Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer.   Cell, 186, (16), 3476-3498.e35. doi: 10.1016/j.cell.2023.07.004. 37541199
Zhou S, Chai D, Wang X, Neeli P, Yu X, Davtyan A, Young K, Li Y. (2023). AI-powered discovery of a novel p53-Y220C reactivator.   Frontiers in oncology, 13, (), 1229696. doi: 10.3389/fonc.2023.1229696. 37593097
Kim BJ, Zheng ZY, Lei JT, Holt MV, Chen A, Peng J, Fandino D, Singh P, Kennedy H, Dou Y, Chica-Parrado MDR, Bikorimana E, Ye D, Wang Y, Hanker AB, Mohamed N, Hilsenbeck SG, Lim B, Asirvatham JR, Sreekumar A, Zhang B, Miles G, Anurag M, Ellis MJ, Chang EC. (2023). Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor-positive Breast Cancers for Targeted Treatment.   Cancer research communications, 3, (7), 1366-1377. doi: 10.1158/2767-9764.CRC-23-0044. 37501682
Sharma S, Woods M, Mehta NU, Sauer T, Parikh KS, Schmuck-Henneresse M, Zhang H, Mehta B, Brenner MK, Heslop HE, Rooney CM. (2023). Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy.   Journal for immunotherapy of cancer, 11, (4), . doi: 10.1136/jitc-2022-006267. 37072346
Baek ML, Lee J, Pendleton KE, Berner MJ, Goff EB, Tan L, Martinez SA, Mahmud I, Wang T, Meyer MD, Lim B, Barrish JP, Porter W, Lorenzi PL, Echeverria GV. (2023). Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment.   Oncogene, 42, (14), 1117-1131. doi: 10.1038/s41388-023-02596-8. 36813854
Ngai H, Barragan GA, Tian G, Balzeau JC, Zhang C, Courtney AN, Guo L, Xu X, Wood MS, Drabek JM, Demberg T, Sands CM, Chauvin-Fleurence CN, Di Pierro EJ, Rosen JM, Metelitsa LS. (2023). LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells.   Cancer immunology research, 11, (2), 171-183. doi: 10.1158/2326-6066.CIR-22-0333. 36484736
Wu T, Li X, Yan G, Tan Z, Zhao D, Liu S, Wang H, Xiang Y, Chen W, Lu H, Liao X, Li Y, Lu Z. (2023). LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.   Journal of experimental & clinical cancer research : CR, 42, (1), 14. doi: 10.1186/s13046-022-02588-8. 36627684
Echeverria GV, Cai S, Tu Y, Shao J, Powell E, Redwood AB, Jiang Y, McCoy A, Rinkenbaugh AL, Lau R, Trevarton AJ, Fu C, Gould R, Ravenberg EE, Huo L, Candelaria R, Santiago L, Adrada BE, Lane DL, Rauch GM, Yang WT, White JB, Chang JT, Moulder SL, Symmans WF, Hilsenbeck SG, Piwnica-Worms H. (2023). Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer.   NPJ breast cancer, 9, (1), 2. doi: 10.1038/s41523-022-00502-1. 36627285
Watanabe N, Mo F, Zheng R, Ma R, Bray VC, van Leeuwen DG, Sritabal-Ramirez J, Hu H, Wang S, Mehta B, Srinivasan M, Scherer LD, Zhang H, Thakkar SG, Hill LC, Heslop HE, Cheng C, Brenner MK, Mamonkin M. (2023). Feasibility and preclinical efficacy of CD7-unedited CD7 CAR T cells for T cell malignancies.   Molecular therapy : the journal of the American Society of Gene Therapy, 31, (1), 24-34. doi: 10.1016/j.ymthe.2022.09.003. 36086817
Janakiraman H, Becker SA, Bradshaw A, Rubinstein MP, Camp ER. (2022). Critical evaluation of an autologous peripheral blood mononuclear cell-based humanized cancer model.   PloS one, 17, (9), e0273076. doi: 10.1371/journal.pone.0273076. 36095023
Kalra R, Chen CH, Wang J, Salam AB, Dobrolecki LE, Lewis A, Sallas C, Yates CC, Gutierrez C, Karanam B, Anurag M, Lim B, Ellis MJ, Kavuri SM. (2022). Poziotinib Inhibits HER2-Mutant-Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer.   Cancer research, 82, (16), 2928-2939. doi: 10.1158/0008-5472.CAN-21-3106. 35736563
Ravindran A, Krieger KL, Kaushik AK, Hovington H, Mehdi S, Piyarathna DWB, Putluri V, Basil P, Rasaily U, Gu F, Dang T, Choi JM, Sonavane R, Jung SY, Wang L, Mehra R, Weigel NL, Putluri N, Rowley DR, Palapattu GS, Guillemette C, Lacombe L, Lévesque É, Sreekumar A. (2022). Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients.   Cells, 11, (15), . doi: 10.3390/cells11152329. 35954173
Souto EP, Dobrolecki LE, Villanueva H, Sikora AG, Lewis MT. (2022). In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts.   Journal of mammary gland biology and neoplasia, 27, (2), 211-230. doi: 10.1007/s10911-022-09520-y. 35697909
Pal P, Millner A, Semina SE, Huggins RJ, Running L, Aga DS, Tonetti DA, Schiff R, Greene GL, Atilla-Gokcumen GE, Frasor J. (2022). Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells.   Cancers, 14, (10), . doi: 10.3390/cancers14102380. 35625985
Tian Z, Yu C, Zhang W, Wu KL, Wang C, Gupta R, Xu Z, Wu L, Chen Y, Zhang XH, Xiao H. (2022). Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone.   ACS central science, 8, (3), 312-321. doi: 10.1021/acscentsci.1c01024. 35355817
Bhat R, Thangavel H, Abdulkareem NM, Vasaikar S, De Angelis C, Bae L, Cataldo ML, Nanda S, Fu X, Zhang B, Schiff R, Trivedi MV. (2022). NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.   Scientific reports, 12, (1), 1972. doi: 10.1038/s41598-022-05949-7. 35121782
Guillen KP, Fujita M, Butterfield AJ, Scherer SD, Bailey MH, Chu Z, DeRose YS, Zhao L, Cortes-Sanchez E, Yang CH, Toner J, Wang G, Qiao Y, Huang X, Greenland JA, Vahrenkamp JM, Lum DH, Factor RE, Nelson EW, Matsen CB, Poretta JM, Rosenthal R, Beck AC, Buys SS, Vaklavas C, Ward JH, Jensen RL, Jones KB, Li Z, Oesterreich S, Dobrolecki LE, Pathi SS, Woo XY, Berrett KC, Wadsworth ME, Chuang JH, Lewis MT, Marth GT, Gertz J, Varley KE, Welm BE, Welm AL. (2022). A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.   Nature cancer, 3, (2), 232-250. doi: 10.1038/s43018-022-00337-6. 35221336
Chen X, Clement M, Hicks MJ, Sarkar P, Gaber MW, Man TK. (2023). LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma.   Genes & diseases, 10, (1), 254-266. doi: 10.1016/j.gendis.2021.12.016. 37013056
Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. (2022). MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.   Nature communications, 13, (1), 245. doi: 10.1038/s41467-021-27921-1. 35017531
Sun H, Cao S, Mashl RJ, Mo CK, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, Mudd JL, Dean DA 2nd, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM, Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX, Aft R, Fuh KC, Schwarz JK, Zevallos JP, Puram SV, Dipersio JF, NCI PDXNet Consortium, Davis-Dusenbery B, Ellis MJ, Lewis MT, Davies MA, Herlyn M, Fang B, Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Chuang JH, Raphael BJ, Ding L. (2022). Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment.   Nature communications, 13, (1), 294. doi: 10.1038/s41467-021-27678-7. 34996889
Dobrolecki LE, Lewis MT. (2022). Surgical Procedure for Implantation of Human Tumor Tissue into the Epithelium-Free Mammary Fat Pad of Immunocompromised Mice to Generate Patient-Derived Xenografts (PDX).   Methods in molecular biology (Clifton, N.J.), 2471, (), 195-207. doi: 10.1007/978-1-0716-2193-6_10. 35175598
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG. (2021). Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.   Cell reports. Medicine, 2, (12), 100471. doi: 10.1016/j.xcrm.2021.100471. 35028612
Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Berman De Ruiz K, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. (2021). Inhibition of GATA2 in prostate cancer by a clinically available small molecule.   Endocrine-related cancer, 29, (1), 15-31. doi: 10.1530/ERC-21-0085. 34636746
Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, Ittmann MM, Gleave ME, Li W. (2021). CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.   Neoplasia (New York, N.Y.), 23, (11), 1147-1165. doi: 10.1016/j.neo.2021.09.005. 34706306
Rogers JH, Gupta R, Reyes JM, Gundry MC, Medrano G, Guzman A, Aguilar R, Conneely SE, Song T, Johnson C, Barnes S, Cristobal CDD, Kurtz K, Brunetti L, Goodell MA, Rau RE. (2021). Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities.   Blood advances, 5, (19), 3876-3890. doi: 10.1182/bloodadvances.2020002408. 34492683
Ting MA, Reuther J, Chandramohan R, Voicu H, Gandhi I, Liu M, Cortes-Santiago N, Foster JH, Hicks J, Nuchtern J, Scollon S, Plon SE, Chintagumpala M, Rainusso N, Roy A, Parsons DW. (2021). Genomic analysis and preclinical xenograft model development identify potential therapeutic targets for MYOD1-mutant soft-tissue sarcoma of childhood.   The Journal of pathology, 255, (1), 52-61. doi: 10.1002/path.5736. 34086347
Mo Y, Wang Y, Zhang S, Xiong F, Yan Q, Jiang X, Deng X, Wang Y, Fan C, Tang L, Zhang S, Gong Z, Wang F, Liao Q, Guo C, Li Y, Li X, Li G, Zeng Z, Xiong W. (2021). Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2.   Molecular cancer, 20, (1), 112. doi: 10.1186/s12943-021-01409-4. 34465340
Sun H, Cao S, Mashl RJ, Mo CK, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, Mudd JL, Dean DA 2nd, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM, Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX, Aft R, Fuh KC, Schwarz JK, Zevallos JP, Puram SV, Dipersio JF, NCI PDXNet Consortium, Davis-Dusenbery B, Ellis MJ, Lewis MT, Davies MA, Herlyn M, Fang B, Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Chuang JH, Raphael BJ, Ding L. (2021). Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.   Nature communications, 12, (1), 5086. doi: 10.1038/s41467-021-25177-3. 34429404
Le DT, Huynh TR, Burt B, Van Buren G, Abeynaike SA, Zalfa C, Nikzad R, Kheradmand F, Tyner JJ, Paust S. (2021). Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft.   JCI insight, 6, (13), . doi: 10.1172/jci.insight.140116. 34081628
Veeraraghavan J, Gutierrez C, Sethunath V, Mehravaran S, Giuliano M, Shea MJ, Mitchell T, Wang T, Nanda S, Pereira R, Davis R, Goutsouliak K, Qin L, De Angelis C, Diala I, Lalani AS, Nagi C, Hilsenbeck SG, Rimawi MF, Osborne CK, Schiff R. (2021). Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models.   NPJ breast cancer, 7, (1), 63. doi: 10.1038/s41523-021-00274-0. 34045483
Konduri V, Joseph SK, Byrd TT, Nawas Z, Vazquez-Perez J, Hofferek CJ, Halpert MM, Liu D, Liang Z, Baig Y, Salsman VS, Oyewole-Said D, Tsimelzon A, Burns BA, Chen C, Levitt JM, Yao Q, Ahmed NM, Hegde M, Decker WK. (2021). A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma.   Science translational medicine, 13, (592), . doi: 10.1126/scitranslmed.abc3196. 33952672
Wang X, Veeraraghavan J, Liu CC, Cao X, Qin L, Kim JA, Tan Y, Loo SK, Hu Y, Lin L, Lee S, Shea MJ, Mitchell T, Li S, Ellis MJ, Hilsenbeck SG, Schiff R, Wang XS. (2021). Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer.   Clinical cancer research : an official journal of the American Association for Cancer Research, 27, (9), 2648-2662. doi: 10.1158/1078-0432.CCR-20-2961. 33542078
Roarty K, Echeverria GV. (2021). Laboratory Models for Investigating Breast Cancer Therapy Resistance and Metastasis.   Frontiers in oncology, 11, (), 645698. doi: 10.3389/fonc.2021.645698. 33777805
Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann MM, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F. (2021). MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT.   The Journal of clinical investigation, 131, (4), . pii: 135465. doi: 10.1172/JCI135465. 33586682
Qasim SL, Sierra L, Shuck R, Kurenbekova L, Patel TD, Rajapakshe K, Wulff J, Nakahata K, Kim HR, Landesman Y, Unger TJ, Coarfa C, Yustein JT. (2021). p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.   Oncogene, 40, (6), 1176-1190. doi: 10.1038/s41388-020-01600-9. 33414491
Woo XY, Giordano J, Srivastava A, Zhao ZM, Lloyd MW, de Bruijn R, Suh YS, Patidar R, Chen L, Scherer S, Bailey MH, Yang CH, Cortes-Sanchez E, Xi Y, Wang J, Wickramasinghe J, Kossenkov AV, Rebecca VW, Sun H, Mashl RJ, Davies SR, Jeon R, Frech C, Randjelovic J, Rosains J, Galimi F, Bertotti A, Lafferty A, O'Farrell AC, Modave E, Lambrechts D, Ter Brugge P, Serra V, Marangoni E, El Botty R, Kim H, Kim JI, Yang HK, Lee C, Dean DA 2nd, Davis-Dusenbery B, Evrard YA, Doroshow JH, Welm AL, Welm BE, Lewis MT, Fang B, Roth JA, Meric-Bernstam F, Herlyn M, Davies MA, Ding L, Li S, Govindan R, Isella C, Moscow JA, Trusolino L, Byrne AT, Jonkers J, Bult CJ, Medico E, Chuang JH, PDXNET Consortium, EurOPDX Consortium. (2021). Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.   Nature genetics, 53, (1), 86-99. doi: 10.1038/s41588-020-00750-6. 33414553
Dustin D, Gu G, Beyer AR, Herzog SK, Edwards DG, Lin H, Gonzalez TL, Grimm SL, Coarfa C, Chan DW, Kim BJ, De La O JP, Ellis MJ, Liu D, Li S, Welm AL, Fuqua SAW. (2021). RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.   British journal of cancer, 124, (1), 191-206. doi: 10.1038/s41416-020-01174-z. 33257837
Guo Z, Primeau T, Luo J, Zhang C, Sun H, Hoog J, Gao F, Huang S, Edwards DP, Davies SR, Aft R, Ding L, Ellis MJ, Li S, Ma CX. (2020). Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models.   Cancers, 12, (12), . doi: 10.3390/cancers12123857. 33371187
Shoghi KI, Badea CT, Blocker SJ, Chenevert TL, Laforest R, Lewis MT, Luker GD, Manning HC, Marcus DS, Mowery YM, Pickup S, Richmond A, Ross BD, Vilgelm AE, Yankeelov TE, Zhou R. (2020). Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine.   Tomography (Ann Arbor, Mich.), 6, (3), 273-287. doi: 10.18383/j.tom.2020.00023. 32879897
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